diff --git a/dev-python/opentelemetry-instrumentation/files/opentelemetry-instrumentation-0.61_beta0-wrapt-2.patch b/dev-python/opentelemetry-instrumentation/files/opentelemetry-instrumentation-0.61_beta0-wrapt-2.patch
new file mode 100644
index 0000000000..a929419928
--- /dev/null
+++ b/dev-python/opentelemetry-instrumentation/files/opentelemetry-instrumentation-0.61_beta0-wrapt-2.patch
@@ -0,0 +1,123 @@
+index e38932e28..37e6c674f 100644
+--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py
++++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/utils.py
+@@ -20,7 +20,11 @@ from importlib import import_module
+ from re import escape, sub
+ from typing import Any, Dict, Generator, Sequence
+ 
+-from wrapt import ObjectProxy
++try:
++    # wrapt 2.0.0+
++    from wrapt import BaseObjectProxy  # pylint: disable=no-name-in-module
++except ImportError:
++    from wrapt import ObjectProxy as BaseObjectProxy
+ 
+ from opentelemetry import context, trace
+ 
+@@ -108,7 +112,11 @@ def unwrap(obj: object, attr: str):
+             ) from exc
+ 
+     func = getattr(obj, attr, None)
+-    if func and isinstance(func, ObjectProxy) and hasattr(func, "__wrapped__"):
++    if (
++        func
++        and isinstance(func, BaseObjectProxy)
++        and hasattr(func, "__wrapped__")
++    ):
+         setattr(obj, attr, func.__wrapped__)
+ 
+ 
+diff --git a/opentelemetry-instrumentation/tests/test_utils.py b/opentelemetry-instrumentation/tests/test_utils.py
+index 5ddd45d69..11a3598bd 100644
+--- a/opentelemetry-instrumentation/tests/test_utils.py
++++ b/opentelemetry-instrumentation/tests/test_utils.py
+@@ -15,7 +15,13 @@
+ import unittest
+ from http import HTTPStatus
+ 
+-from wrapt import ObjectProxy, wrap_function_wrapper
++from wrapt import wrap_function_wrapper
++
++try:
++    # wrapt 2.0.0+
++    from wrapt import BaseObjectProxy  # pylint: disable=no-name-in-module
++except ImportError:
++    from wrapt import ObjectProxy as BaseObjectProxy
+ 
+ from opentelemetry.context import (
+     _SUPPRESS_HTTP_INSTRUMENTATION_KEY,
+@@ -263,23 +269,23 @@ class UnwrapTestCase(unittest.TestCase):
+     def test_can_unwrap_object_attribute(self):
+         self._wrap_method()
+         instance = WrappedClass()
+-        self.assertTrue(isinstance(instance.method, ObjectProxy))
++        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
+ 
+         unwrap(WrappedClass, "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+ 
+     def test_can_unwrap_object_attribute_as_string(self):
+         self._wrap_method()
+         instance = WrappedClass()
+-        self.assertTrue(isinstance(instance.method, ObjectProxy))
++        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
+ 
+         unwrap("tests.test_utils.WrappedClass", "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+ 
+     def test_raises_import_error_if_path_not_well_formed(self):
+         self._wrap_method()
+         instance = WrappedClass()
+-        self.assertTrue(isinstance(instance.method, ObjectProxy))
++        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
+ 
+         with self.assertRaisesRegex(
+             ImportError, "Cannot parse '' as dotted import path"
+@@ -287,23 +293,23 @@ class UnwrapTestCase(unittest.TestCase):
+             unwrap("", "method")
+ 
+         unwrap(WrappedClass, "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+ 
+     def test_raises_import_error_if_cannot_find_module(self):
+         self._wrap_method()
+         instance = WrappedClass()
+-        self.assertTrue(isinstance(instance.method, ObjectProxy))
++        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
+ 
+         with self.assertRaisesRegex(ImportError, "No module named 'does'"):
+             unwrap("does.not.exist.WrappedClass", "method")
+ 
+         unwrap(WrappedClass, "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+ 
+     def test_raises_import_error_if_cannot_find_object(self):
+         self._wrap_method()
+         instance = WrappedClass()
+-        self.assertTrue(isinstance(instance.method, ObjectProxy))
++        self.assertTrue(isinstance(instance.method, BaseObjectProxy))
+ 
+         with self.assertRaisesRegex(
+             ImportError, "Cannot import 'NotWrappedClass' from"
+@@ -311,7 +317,7 @@ class UnwrapTestCase(unittest.TestCase):
+             unwrap("tests.test_utils.NotWrappedClass", "method")
+ 
+         unwrap(WrappedClass, "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+ 
+     # pylint: disable=no-self-use
+     def test_does_nothing_if_cannot_find_attribute(self):
+@@ -320,6 +326,6 @@ class UnwrapTestCase(unittest.TestCase):
+ 
+     def test_does_nothing_if_attribute_is_not_from_wrapt(self):
+         instance = WrappedClass()
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
+         unwrap(WrappedClass, "method")
+-        self.assertFalse(isinstance(instance.method, ObjectProxy))
++        self.assertFalse(isinstance(instance.method, BaseObjectProxy))
diff --git a/dev-python/opentelemetry-instrumentation/opentelemetry-instrumentation-0.61_beta0.ebuild b/dev-python/opentelemetry-instrumentation/opentelemetry-instrumentation-0.61_beta0.ebuild
index c7a1b33a1d..20f9279de6 100644
--- a/dev-python/opentelemetry-instrumentation/opentelemetry-instrumentation-0.61_beta0.ebuild
+++ b/dev-python/opentelemetry-instrumentation/opentelemetry-instrumentation-0.61_beta0.ebuild
@@ -41,17 +41,18 @@ RDEPEND="
 	>=dev-python/wrapt-1.0.0[${PYTHON_USEDEP}]
 "
 
+PATCHES=(
+	"${FILESDIR}/${P}-wrapt-2.patch"
+)
+
 EPYTEST_PLUGINS=()
 distutils_enable_tests pytest
 
-EPYTEST_DESELECT=(
-	# TODO Investigate test failures
-	opentelemetry-instrumentation/tests/test_utils.py::UnwrapTestCase::test_can_unwrap_object_attribute
-	opentelemetry-instrumentation/tests/test_utils.py::UnwrapTestCase::test_can_unwrap_object_attribute_as_string
-	opentelemetry-instrumentation/tests/test_utils.py::UnwrapTestCase::test_raises_import_error_if_cannot_find_module
-	opentelemetry-instrumentation/tests/test_utils.py::UnwrapTestCase::test_raises_import_error_if_cannot_find_object
-	opentelemetry-instrumentation/tests/test_utils.py::UnwrapTestCase::test_raises_import_error_if_path_not_well_formed
-)
+src_prepare() {
+	# Apply patch at root of the monorepo (only needed till 0.62b0 release)
+	cd .. || die
+	distutils-r1_src_prepare
+}
 
 python_test() {
 	cp -a "${BUILD_DIR}"/{install,test} || die