diff --git a/dev-python/prefab-ui/Manifest b/dev-python/prefab-ui/Manifest
new file mode 100644
index 0000000000..51ce0a1412
--- /dev/null
+++ b/dev-python/prefab-ui/Manifest
@@ -0,0 +1,3 @@
+DIST prefab_ui-0.14.1.tar.gz 3897953 BLAKE2B 7a873dbe6a592d9a37eea6b393e44abb1e30e08599099dfb712ab422955455f4c0a69fe1b6c81b6e8bfd82ac2917bcd32b88b4622142dc8cfaeadbf9860b149a SHA512 f31063972d65d3f7b3c3ab6fe66b40a037712cf5cdd7c553f2d8c2a7ee61d4da74b1b1885664438202c50cb7aa595a29e973f4ab39215a4f2cd883f1bbbc0aac
+DIST prefab_ui-pyodide-v2026.03.28.sha256 437 BLAKE2B d314f804ae6b0b099f4336cc3adbe1df7951015dbaac2f12aa07d9308361f7a2a419169d4d0544fa439b755dd0f79b6234b4918d49328e7a3266ff1f577506b7 SHA512 4f3fec7775aecba2a1d67b0a9b4961ee9f09e95dd945c4e65cdb1786a97bb763337b4340e0734a7ef7f1c89394d5c6e73171068fc3504f867018d1baf59909a8
+DIST prefab_ui-sandbox-v2026.03.28.tar.xz 6024436 BLAKE2B 27d83d72cf356715d96bce53853399624cef59a215e8a2ca42a54e79586e2a7c8ffd8fa9585236ec4be99eb0617ea725fc6b45302d3420633fc72f6aa8d4ab8a SHA512 c10e0ce3bc2f7052b17767054037ba97cf8faab0b6eab0d1099fb2a2cff43053bcbaa032b76e1da966dbf14e8715bc1152e063f62df71e9945978d23f0425ea8
diff --git a/dev-python/prefab-ui/metadata.xml b/dev-python/prefab-ui/metadata.xml
new file mode 100644
index 0000000000..f15fb580fd
--- /dev/null
+++ b/dev-python/prefab-ui/metadata.xml
@@ -0,0 +1,12 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE pkgmetadata SYSTEM "https://www.gentoo.org/dtd/metadata.dtd">
+<pkgmetadata>
+	<maintainer type="person">
+		<email>falbrechtskirchinger@gmail.com</email>
+		<name>Florian Albrechtskirchinger</name>
+	</maintainer>
+	<upstream>
+		<remote-id type="pypi">prefab-ui</remote-id>
+		<remote-id type="github">PrefectHQ/prefab</remote-id>
+	</upstream>
+</pkgmetadata>
diff --git a/dev-python/prefab-ui/prefab-ui-0.14.1.ebuild b/dev-python/prefab-ui/prefab-ui-0.14.1.ebuild
new file mode 100644
index 0000000000..c70d2e95cc
--- /dev/null
+++ b/dev-python/prefab-ui/prefab-ui-0.14.1.ebuild
@@ -0,0 +1,102 @@
+# Copyright 2026 Gentoo Authors
+# Distributed under the terms of the Apache License 2.0
+
+EAPI=8
+
+PYTHON_COMPAT=( python3_{12..14} )
+DISTUTILS_USE_PEP517=hatchling
+inherit distutils-r1 pypi
+
+DESCRIPTION="The agentic frontend framework that even humans can use"
+HOMEPAGE="
+	https://prefab.prefect.io/
+	https://github.com/PrefectHQ/prefab
+	https://pypi.org/project/prefab-ui/
+"
+
+# prefab-ui uses Pyodide (Wasm CPython) within Deno for its sandbox.
+# We vendor both the Deno runtime dependencies and the Wasm Python wheels
+# to allow the test suite to execute inside the Portage network sandbox.
+#
+# Sandbox vendor tarball contents and checksums generated via:
+# src/prefab_ui/sandbox $ deno cache --vendor --lock=deno.lock runner.js
+# ... and:
+# $ u="https://cdn.jsdelivr.net/pyodide/v0.27.4/full"; \
+# mkdir pyodide_packages && cd pyodide_packages && wget -q "$u/pyodide-lock.json" && \
+# python -c 'import json, sys; pkgs=set(sys.argv[1].split()); f=sys.stderr; \
+# [(print(v["file_name"]), f.write(v["sha256"] + "  " + v["file_name"] + "\n")) \
+# for k, v in json.load(sys.stdin)["packages"].items() if k in pkgs]' \
+# "annotated-types pydantic pydantic-core typing-extensions" \
+# <pyodide-lock.json 2>../checksums.sha256 | xargs -I {} wget -q "$u/{}"
+
+# Vendored test dependencies
+VD_TAG=2026.03.28.0
+VD_BASE_URI="https://github.com/falbrechtskirchinger/overlay-assets/releases/download"
+SRC_URI+="
+	test? (
+		${VD_BASE_URI}/v${VD_TAG}/${PN//-/_}-sandbox-v${VD_TAG%.*}.tar.xz
+		${VD_BASE_URI}/v${VD_TAG}/${PN//-/_}-pyodide-v${VD_TAG%.*}.sha256
+	)
+"
+
+LICENSE="Apache-2.0"
+SLOT="0"
+KEYWORDS="~amd64 ~arm64"
+
+RDEPEND="
+	dev-lang/deno-bin
+	>=dev-python/pydantic-2.11[${PYTHON_USEDEP}]
+	>=dev-python/cyclopts-4[${PYTHON_USEDEP}]
+	>=dev-python/rich-13[${PYTHON_USEDEP}]
+"
+BDEPEND="
+	test? (
+		dev-python/jsonschema[${PYTHON_USEDEP}]
+	)
+"
+
+EPYTEST_PLUGINS=( pytest-{asyncio,timeout} )
+EPYTEST_XDIST=1
+distutils_enable_tests pytest
+
+src_test() {
+	local -x DENO_NO_REMOTE=1
+
+	# Check cache completness
+	pushd ..>/dev/null || die
+	echo '{"vendor": true}' >deno.json || die
+	deno cache --lock=deno.lock --frozen \
+		"${S}/src/prefab_ui/sandbox/runner.js" || die
+	popd >/dev/null || die
+
+	# Verify vendored wheels
+	pushd "${WORKDIR}/pyodide_packages" >/dev/null || die
+	sha256sum -c "${DISTDIR}/${PN//-/_}-pyodide-v${VD_TAG%.*}.sha256" || die
+	popd >/dev/null || die
+
+	distutils-r1_src_test
+}
+
+python_test() {
+	cp -a "${BUILD_DIR}"/{install,test} || die
+	local -x PATH=${BUILD_DIR}/test/usr/bin:${PATH}
+
+	local base_dir="${BUILD_DIR}/test/usr/lib/${EPYTHON}"
+	local sandbox_dir="${base_dir}/site-packages/prefab_ui/sandbox"
+
+	cp -a "${S}/skills" "${base_dir}" || die
+
+	# Copy vendored Deno dependencies
+	cp -a \
+		"${WORKDIR}/deno."{lock,json} \
+		"${WORKDIR}/node_modules" \
+		"${WORKDIR}/vendor" "${sandbox_dir}/" || die
+	# Copy vendored wheels
+	cp -a "${WORKDIR}/pyodide_packages/"* "${sandbox_dir}/node_modules/pyodide/" || die
+
+	# Show full error messages from Pyodide
+	sed -i 's/err\[-1000:\]/err/' "${sandbox_dir}/_pyodide.py" || die
+
+	local -x DENO_NO_REMOTE=1
+	epytest
+}